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Evaluation of Ginger Oleoresin in Carbon Tetrachloride Induced Hepatotoxicity in Rats


Ravinder KhatriKashish Bhardwaj, Akshay SharmaSrijana Tamang, Kiran, Umesh Chettri and Arvind SharmaAssistant Professor, Shiva Institute of B. Pharmacy, Bilaspur, Himachal Pradesh, India


Ginger oleoresin, hepatotoxicity


The present study evaluated the hepatoprotective activity of ginger oleoresin against Carbontetrachloride induced liver toxic damage in rats. Rats were divided into six groups. Hepatotoxicity was induced by the administration of a single intraperitoneal dose (2ml/kg) of Carbontetrachloride in experimental rats. Post-treatment with Ginger oleoresin at 300 and 600mg/kg dose given by oral route was carried out to find their protective effects against carbontetrachloride induced hepatic injury. Biochemical parameter for oxidative stress, inflammation and lipid profile along with genotoxicity and histological changes in rat serum and liver were studied. Silymarin was used as standard hepatoprotective agent. Extracted oleoresin dose dependently provided hepatoprotective effects.The hepatoprotective action of ginger oleoresin may be related to its free radical scavenging,anti-inflammatory and hypolipidemic activity and concluded to be partly mediated by its active constituent’s 6-gingerol, shogaol and zingerone. -phospate; CCl3 *, Trichloromethyl free radical; CCl3 OO*, Trichloromethyl peroxy radical; ROS, Reactive oxygen species; iNOS, inducible nitric oxide synthase; NO, Nitric oxide, VLDL, Very low density lipoprotein.



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