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Structural Variations Induced by Temperature Changes in Rotavirus VP6 Protein Immersed in an Electric Field and Their Effects on Epitopes of The Region 300-396

Author(s):

C. Peña-Negrete, M.A. Fuentes-Acosta, J. Mulia, L.A. Mandujano-Rosas and D. Osorio-González, Molecular Biophysics Laboratory of the Faculty of Sciences, Autonomous University of the State of Mexico, Mexico

Keywords:

Rotavirus, VP6, Antigenic determinants

Abstract:

Rotavirus diarrhea is an infectious intestinal disease that causes about 215 thousand deaths annually in infants under five years old. This virus is formed by three layers of concentric proteins that envelop its genome, from which VP6 structural protein is the most conserved among rotavirus serotypes and an excellent vaccine candidate. Recent studies have shown that structural proteins are susceptible to losing their biological function when their conformation is modified by moderate temperature increments, and in the case of VP6, its antigen efficiency decreases.

URL:

https://jnp.chitkara.edu.in/index.php/jnp/article/view/221/185

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