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Synthesis and Characterization of Novel Schiff base Cu(II) Complexes: Antimicrobial and Molecular docking Studies

Synthesis and Characterization of Novel Schiff


N2O2 type complexes of C+2uion have been synthesized by the reaction of Salicylaldehyde / 3,4-diamino benzophenone/acetylacetone and glutaric anhydride. The ligands and respective metal complexes were established through spectroscopic data (FT-IR, UV-Vis,1H NMR, and 13C NMR). They are non-electrolytic in nature as their molar conductivities (ΛM) in DMSO of 10-3 M solution from the EPR study the complexes proposed to be octahedral geometry. All the metal complexes have been screened for their antibacterial activity and predicted binding affinity using molecular docking studies


AP Arumugam, G Elango and S Guhanathan


EPR, 3,4-diamino benzophenone, Antimicrobial Activity, Molecular Docking.



  • Desai K.R., Patel R.B., Desai P.S., and Chikhali K.H., J Indian Chem Soc.,2003, 80, 138.
  • Green D. R., and Reed J. C., “Mitochondria and apoptosis,” Science, 1998, vol. 281, no. 5381, 1309–1312.
  • Cao Y.Ma, L., Kavabata T., Yoshino T., Yang B. B., and Okada S., Free Radical Biologyand Medicine, 1998, vol. 25, no. 4-5, 568–575.
  • LiangF., WuC., LinH., “Copper complex of hydroxyl-substituted Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, 2469– 2472.
  • Hegg E. L., and Burstyn J. N., Coordination Chemistry Reviews, 1998, vol. 173, no. 1, 133–165.
  • GandinV. V., PorchiaM., TisatoF., ZanellaA., SeverinE., DolmellaA., and MarzanoC., Journal of Medicinal Chemistry, 2013, 56, 7416. 58.
  • Gonzalez-AlvarezM., Pascual-AlvarezA., AgudoL. C., CastineirasA., Liu- GonzalezM., BorrasJ. and Alzuet-PinaG., Dalton Transactions, 2013, 42, 10244.
  • Rayees Ahmad Shiekh, Ismail Ab Rahman, Maqsood Ahmad Malik, NorhayatiLuddin, Sam’an Malik Masudi1, Shaeel Ahmed Al-Thabaiti2., Int. J. Electrochem. Sci., 8, 2013, 6972–6987.
  • MozaffarAsadi, HajarSepehrpour and KhosroMohammadi.,J. Serb. Chem. Soc. 76 (1) 63–74, 2011, JSCS–4100.
  • Nagajothi A, Kiruthika A, Chitra S and Parameswari. K., Int. J. of Research in Pharmaceutical and Biomedical Sciences ISSN: 2229-3701.
  • Azza A. A. Abou – Hussein, Wolfgang Linert., SpectrochimicaActa (A), 2012, 95, 596–609.
  • Farouk Kandil, Mohamad Khaled Chebani and Wail Al Zoubi, International Scholarly Research Network, ISRN Organic chemistry, 2012, Article ID 208284, 8 pages.
  • Raman N., Baskaran T., Selvan A., and Jeyamurugan R., J. Iran. Chem. Res. 2008, 1, 129–139.
  • Pushpanathan V., and Suresh Kumar D., Int. J. Inorg. And BioInorg. Chem.,2013, ISSN 2249-8540.
  • Usharani M., Akila E., Jayaseelan P., and Rajavel R., International Journal of Scientific & Engineering Research, July-2013 Volume4, Issue7, ISSN 2229-5518
  • Patil S. A., Unki S. N., Kulkarni A. D., Naik V. H., and Badami P. S., SpectrochimicaActa A, 2011, 79, No. 5, 1128–1136.
  • Palaniandavar M., and Natarajan C., Aust. J. Chem.,1980, 33, 737.
  • Khulbe R.C., Bhoom Y.K., and Singh R.P., J.Chem.Soc.,1981, 50, 840.
  • MagdyShebl, Saied M.E., Khalil, Saleh A., Ahmed, Hesham A.A. Medien., J. Mol. Struct, 2010, 980, 39–50.
  • Maneiro M., Bermejo M.R., Fondo M., Gonzalez A.M., Sanmartın J., Garcıa- Monteagudo J.C., Pritchard R.G., Tyryshkin A.M., Polyhedron 2001, 20, 711–719.
  • MounyrBalouiri, MoulaySadiki, SaadKoraichiIbnsouda, J. Pharm. Analysis. 2016, 6, 71–79.
  • O. Trott, A. J. Olson, AutoDockVina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, Journal of computational chemistry, 2010, 31, 455–461.
  • Ferraro, G., Massai, L., Messori, L., Merlino, A., Cisplatin binding to human serum albumin: a structural study, Chem. Commun, (Camb.), 2015, 51, 9436–9439